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. 2018 Jul 20;9(56):30919–30935. doi: 10.18632/oncotarget.25778

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Copyright: © 2018 Ichim et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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The effect of a curative (CUR) and preventive (PREV) administration of the probiotic with digestive enzymes supplement as compared to a control SHIME (CTRL) on luminal Lactobacillus (left panels) and Bifidobacterium (right panels) levels (16S rDNA copies/mL) in the proximal (PC; top panels) and distal colon (DC; bottom panels). The data are represented for the control weeks (C1, C2) and treatment weeks (TR1, TR2, TR3, and TR4. It should be noted that 5-FU/vancomycin was administered to the system in TR1 and discontinued in TR2–TR4. Preventative administration of the probiotic with digestive enzymes supplement was being administered throughout the control periods (C1 and C2), while curative supplementation of the probiotic with digestive enzymes formulation was initiated and maintained at TR1-TR4. (^*) indicates statistically significant differences relative to the preceding period, while different letters indicate a statistical difference between different treatments; p < 0.05.