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. 2018 Jul 20;9(56):30919–30935. doi: 10.18632/oncotarget.25778

Figure 4. Changes in the dominant phyla of beneficial gut microbes, Bacteriodetes and Firmicutes, by the probiotic with digestive enzymes supplement.

Figure 4

The effect of a curative (CUR) and preventive (PREV) administration of the probiotic with digestive enzymes supplement as compared to a control SHIME (CTRL) on luminal Bacteroidetes, and Firmicutes levels (16S rDNA copies/mL) in the proximal (PC; top panels) and distal colon (DC; bottom panels). The data are represented for the control weeks (C1, C2) and treatment weeks (TR1, TR2, TR3, and TR4. It should be noted that 5-FU/vancomycin was administered to the system in TR1 and discontinued in TR2-TR4. Preventative administration of the probiotic with digestive enzymes supplement was being administered throughout the control periods (C1 and C2), while curative supplementation of the probiotic with digestive enzymes formulation was initiated and maintained at TR1-TR4. (*) indicates statistically significant differences relative to the preceding period, while different letters indicate a statistical difference between different treatments; p < 0.05.