Table 3. The p-values, fold changes, sensitivity, specificity, and AUC values of HSPE1 ROC curves.

Expression level of HSPE1	Different comparison	Fold change (BC/control)	p-value for diagnosis	AUC (sensitivity/specificity)	Optimal cutoff point (score for tissue; ng/ml for urine)
Tissue	Bladder cancer (n = 92) vs Adjacent normal (n = 19)	4.68	<0.0001	0.92 (92.39%/78.95%)	110
Urine	Bladder cancer (n = 126) vs Hernia (n = 142)	2.51	<0.01	0.60 (75.40%/42.25%)	0.074
	Low-grade BC (n = 42) vs Hernia (n = 142)	2.48	<0.05	0.60 (59.52%/68.31%)	0.204
	Early-stage BC (n = 98) vs Hernia (n = 142)	2.46	<0.01	0.61 (52.04%/68.31%)	0.204
	Bladder cancer (n = 126) vs Hematuria (n = 67)	3.48	<0.01	0.63 (57.94%/65.67%)	0.155
	Bladder cancer (n = 126) vs Urinary tract infection (n = 59)	3.87	<0.01	0.63 (38.10%/84.75%)	0.261