Skip to main content
. 2018 Jun 26;61(15):6592–6608. doi: 10.1021/acs.jmedchem.8b00172

Table 1. In Vitro Profile of a Selected MOT Confirmed Hit.

graphic file with name jm-2018-001722_0006.jpg

MIC (H37RvLP) 0.72 ± 0.30 (n = 14)
Vero cytotoxicity Vero > 100 μM
LLE 4.2
PFI 4
Measure CHI Log D 2
Kinetic solubility >250 μM
MW 332
Clog P/D 2.6/2.0
TPSA 65
Microsomal clearance Mouse = 19 mL·min−1·g−1
  Human = 3.5 mL·min−1·g−1
CYP inhibition (M) 2D6 (5), 2C9 (5.1), 1A2 (<5), 2C19 (5.9)