Table 10. Efficacy of 37 against M. tuberculosis in an Acute Murine Model of Intratracheal Infection.
log
CFUs per mouse (lungs) |
|||||||
---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | mean | SD | |
no treatment (day 9) | 6.8 | 6.8 | 6.5 | 6.9 | 7.0 | 6.8 | 0.2 |
Moxifloxacin: 30 mg/kg 8 days | 3.8 | 4.4 | 4.0 | 3.9 | 3.8 | 4.0 | 0.3 |
37: 100 mg/kg 4 days | 6.1 | 5.8 | 6.0 | 0.2 |