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. 2018 Jun 26;61(15):6592–6608. doi: 10.1021/acs.jmedchem.8b00172

Table 10. Efficacy of 37 against M. tuberculosis in an Acute Murine Model of Intratracheal Infection.

  log CFUs per mouse (lungs)
   
  1 2 3 4 5 mean SD
no treatment (day 9) 6.8 6.8 6.5 6.9 7.0 6.8 0.2
Moxifloxacin: 30 mg/kg 8 days 3.8 4.4 4.0 3.9 3.8 4.0 0.3
37: 100 mg/kg 4 days 6.1 5.8       6.0 0.2