Table 4. Phenyl Ring and Ethyl Linker SAR.

^aMinimum inhibitory concentration (MIC₉₀) is the minimum concentration required to inhibit the growth of M. tuberculosis in liquid culture. Data are the average ± standard deviation of a minimum of two independent experiments; numbers of experiments is given (n).

^bInhibitory concentration (IC₅₀) is the concentration required to inhibit growth of Vero cells by 50%. Data are the average ± standard deviation of a minimum of two independent experiments; numbers of experiments is given (n).

^cIntrinsic clearance (Cli) using CD1 mouse liver microsomes