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. 2018 Jun 26;61(15):6592–6608. doi: 10.1021/acs.jmedchem.8b00172

Table 5. Core Replacement SAR.

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a

Minimum inhibitory concentration (MIC90) is the minimum concentration required to inhibit the growth of M. tuberculosis in liquid culture. Data are the average ± standard deviation of a minimum of two independent experiments; numbers of experiments is given (n).

b

Inhibitory concentration (IC50) is the concentration required to inhibit growth of Vero cells by 50%. Data are the average ± standard deviation of a minimum of two independent experiments; numbers of experiments is given (n).

c

Intrinsic clearance (Cli) using CD1 mouse liver microsomes