Skip to main content
. 2018 Jun 26;61(15):6592–6608. doi: 10.1021/acs.jmedchem.8b00172

Table 8. MDCK Profiling of Selected Compounds.

ID MW log P TPSA HBD A → B Papp 1 × 10e–6 cm/s B → A Papp 1 × 10e–6 cm/s P-gp Efflux B→ A/A → B
Quinidine 324 2.6 45 1 4 89 20
Verapamil 454 3.8 64 0 14 29 2
Atenolol 266 0.2 85 4 1 1 1
Metoprolol 267 1.8 51 2 55 40 0.7
1 332 2.6 65 2 45 37 0.8
37 416 3.3 74 2 25 20 0.8
18 346 2.2 65 2 62 53 0.8
46 312 1.1 74 2 19 35 2
56 344 2.8 65 2 51 37 0.7