Table 8. MDCK Profiling of Selected Compounds.
ID | MW | log P | TPSA | HBD | A → B Papp 1 × 10e–6 cm/s | B → A Papp 1 × 10e–6 cm/s | P-gp Efflux B→ A/A → B |
---|---|---|---|---|---|---|---|
Quinidine | 324 | 2.6 | 45 | 1 | 4 | 89 | 20 |
Verapamil | 454 | 3.8 | 64 | 0 | 14 | 29 | 2 |
Atenolol | 266 | 0.2 | 85 | 4 | 1 | 1 | 1 |
Metoprolol | 267 | 1.8 | 51 | 2 | 55 | 40 | 0.7 |
1 | 332 | 2.6 | 65 | 2 | 45 | 37 | 0.8 |
37 | 416 | 3.3 | 74 | 2 | 25 | 20 | 0.8 |
18 | 346 | 2.2 | 65 | 2 | 62 | 53 | 0.8 |
46 | 312 | 1.1 | 74 | 2 | 19 | 35 | 2 |
56 | 344 | 2.8 | 65 | 2 | 51 | 37 | 0.7 |