Table 2. Pathway mapping of intracellular deregulated proteins and the differential secretome.
| PATHWAY | PROTEINS (6hpi) | PROTEINS (10hpi) |
|---|---|---|
| Dendritic Cell Maturation | LTA, COL1A1 | IL15, COL1A1 |
| CXCR4 Signaling | CXCL12, RACK1, GNB2 | MYL6, CXCL12, RACK1 |
| CCR5 Signaling in Macrophages | CCL5, RACK1, GNB2 | CCL5, RACK1 |
| ERK5 Signaling | LIF, YWHAB | YWHAG, LIF |
| Glucocorticoid Receptor Signaling | A2M, TAF15, TGFB3, HSPA1A/HSPA1B, CCL5, ARID2, SERPINE1, CCL11, IL13, SMARCC2, KRT9, KRT14 | A2M, IL2, CCL5, ARID2, SERPINE1, HSP90AB1, KRT14 |
| Axonal Guidance Signaling | CXCL12, CDC42, RACK1, ITGA3, RAC2, GNB2 | MYL6, CXCL12, CDC42, ACTR2, RACK1, ITGA3, ARPC5L, RAC2, ARPC1A |
| Crosstalk between Dendritic Cells and Natural Killer Cells | TLN1, ACTG1, LTA | IL2, IL15, ACTG1 |
| Leukocyte Extravasation Signaling | CXCL12, CDC42, ACTG1, ITGA3, RAC2 | MYL6, CXCL12, CDC42, ACTG1, ITGA3, RAC2 |
| Granulocyte Adhesion and Diapedesis | CXCL12, CCL26, CCL22, CCL5, ITGA3, CXCL10, CCL15, CCL11 | CXCL6, CXCL12, CCL5, ITGA3, CCL20, CSF3 |
| Agranulocyte Adhesion and Diapedesis | CXCL12, CCL26, CCL22, ACTG1, CCL5, ITGA3, CXCL10, CCL15, CCL11 | CXCL6, MYL6, CXCL12, ACTG1, CCL5, ITGA3, CCL20 |
| Ephrin B Signaling | CXCL12, CDC42, RACK1, RAC2, GNB2 | CXCL12, CDC42, RACK1, RAC2 |
| Ephrin Receptor Signaling | CXCL12, CDC42, RACK1, ITGA3, RAC2, GNB2 | CXCL12, CDC42, ACTR2, RACK1, ITGA3, ARPC5L, RAC2, ARPC1A |
| Antiproliferative Role of TOB in T Cell Signaling | TGFB3, PABPC1, PABPC4 | IL2, PABPC1, PABPC4 |
| HMGB1 Signaling | TGFB3, CDC42, LTA, LIF, SERPINE1, IL13 | IL2, CDC42, LIF, SERPINE1 |
| Wnt/β-catenin Signaling | TGFB3, RPS27A | |
| Aryl Hydrocarbon Receptor Signaling | TGFB3, MCM7 | |
| p38 MAPK Signaling | TGFB3, H3F3A/H3F3B | |
| Fc Epsilon RI Signaling | IL13, RAC2 | |
| Cell Cycle: G1/S Checkpoint Regulation | TGFB3, PA2G4 | |
| Pancreatic Adenocarcinoma Signaling | TGFB3, CDC42, PA2G4 | |
| RAR Activation | TGFB3, PML, ARID2, SMARCC2 | |
| TGF-β Signaling | TGFB3, CDC42, SERPINE1 | |
| Cyclins and Cell Cycle Regulation | TGFB3, PA2G4, CDK1 | |
| CCR3 Signaling in Eosinophils | CCL26, RACK1, CCL11, GNB2 | |
| Protein Kinase A Signaling | HIST1H1C, TGFB3, RACK1, H3F3A/H3F3B, HIST1H1E, HIST1H1B, YWHAB, GNB2 | |
| Tight Junction Signaling | CSTF3, TGFB3, CDC42, CSTF2, ACTG1, CPSF1, CPSF2, NUDT21 | |
| PKCθ Signaling in T Lymphocytes | IL2, RAC2 | |
| Telomerase Signaling | IL2, HSP90AB1 | |
| CD28 Signaling in T Helper Cells | IL2, CDC42, ACTR2, ARPC5L, ARPC1A | |
| Recognition of Bacteria and Viruses | EIF2S1, IL2, CCL5, LIF |
Cytokines and growth factors deregulated at extracellular level during Delta-24RGD infection were jointly analyzed with intracellular deregulated proteins. Pathways represented at 6 and 10hpi by IPA software are shown.