Table 3. Cochrane Risk of Bias.

Name	Random sequence	Allocation concealment	Blinding of participants and personnel	Blinding of outcome assessment	Incomplete outcome data	Reporting bias
Byun et al [12]	Not reported	Not reported	Blinded	Not reported	No	Not reported
	Unclear	Unclear	Low risk	Unclear	Low Risk	Unclear
Lee et al [8]	Central randomization with computer generated codes	Not reported	Blinded (complete)	Not reported	No	Not reported
	Low risk	Unclear	Low risk	Unclear	Low Risk	Unclear
Corte et al [6]	Central randomization with computerized algorithm	No	Single arm blinded*	Not reported	No	Not reported
	Low risk	High risk	Low risk	Unclear	Low risk	Unclear
Brouwer et al [11]	Not reported	Not reported	Not reported	Yes	No	Not reported
	Unclear	Unclear	Unclear	Low risk	Low risk	Unclear
Rondonotti et al [10]	Central randomization using computer generated list	Randomization list	Single arm blinded*	Not reported	No	Not reported
	Low risk	Low risk	Low risk	Unclear	Low risk	Unclear
Ristnikankre et al [9]	Block randomization using sealed envelopes	Sealed and coded envelopes	Blinded (complete)	Not reported	No	Not reported
	Low risk	Low risk	Low risk	Unclear	Low risk	Unclear
Santos et al [7]	Web generated	Sealed envelopes	Blinded	Yes	No	Not reported
	Low risk	Low risk	Low risk	Low risk	Low risk	Unclear

*Administering nurse not blinded.