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. 2018 Aug 8;7:212540. doi: 10.7573/dic.212540

Figure 2. PARP-1 protein domains.

Figure 2

PARP-1 and PARP-2′s protein domains include zing finger DNA-binding domains and a nuclear localization signal on the N-terminus. Their catalytic domain with NAD+ binding site is located on the C-terminus. Unique to PARP-1 is a BRCT domain upon which PARP-1 auto-PARylates itself, undergoing a conformational change that frees the protein from its DNA target, and a caspase cleavage site that separates the DNA-binding domains from PARP-1′s DNA repair functions.2,3

BRCT, BRCA1 C-terminus domain; NAD+, Nicotinamide adenine dinucleotide; NLS, nuclear localization signal; PARP-1, poly-ADP-ribosyl polymerase 1; PARylation, poly(ADP-ribose)ylation; Zn, zinc finger DNA-binding domains.