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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Struct Biol. 2018 May 11;203(3):255–262. doi: 10.1016/j.jsb.2018.05.003

Figure 1.

Figure 1.

A. Reported OI fonns within and adjacent to the essential integrin binding sequence 502GFPGER507 (Galicka et al., 2003; Lindahl et al., 2015; Marini et al., 2007; Venturi et al., 2006; Wang et al., 2009; Wu et al., 2015). The essential integrin binding motif GFPGER was highlighted in green; the Gly residues studied in this work were underlined; the residue replacing Gly is shown below, together with the phenotypic severity of the OI (nonlethal OI case: black; lethal OI case: red; G505S: OI-IV; G508A: OI-III; G508V: OI-II; G511S: OI-III; G511D: OI-II; G514A: OI-III; G517S: OI-II). B. Schematic diagram of the recombinant bacterial constructs VCL-Int and Gly missense mutations, highlighting the insertion of (Gly-Xaa-Yaa)6 triplets from human α1(I) collagen chain.