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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Am J Surg Pathol. 2018 Sep;42(9):1166–1181. doi: 10.1097/PAS.0000000000001111

Figure 4.

Figure 4

Adult ESC RCC with predominant papillary architecture shown to harbor TSC mutation (New ESC #4). This was a 1.8 cm renal tumor in a 47-year-old female. The neoplasm had dominant papillary architecture throughout (A) with only one focal (<1% of tumor) area of more typical solid growth (B, left of figure). On high power examination, the neoplasm demonstrated the prominent granular eosinophilic cytoplasm and granular cytoplasmic stippling (C), along with the patchy immunoreactivity for cytokeratin 20 (D) that are typical of ESC. This neoplasm demonstrated two TSC1 mutations.