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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Am J Surg Pathol. 2018 Sep;42(9):1166–1181. doi: 10.1097/PAS.0000000000001111

Figure 6.

Figure 6

Previously unclassified RCC with features of ESC now shown to harbor TSC mutation. This patient was a 15-year-old female who presented with nausea and was found to have a renal tumor. The neoplasm was unencapsulated (A) and entrapped negative renal tubules (B). The striking feature of the neoplastic cells was their prominent cell membrane giving them a plant-like appearance, along with prominent cytoplasmic vacuolization and prominent nucleoli (C). Granular cytoplasmic stippling was not seen. The neoplasm demonstrated patchy immunoreactivity for cathepsin k with strong staining in the area highlighted in this image (D). This neoplasm demonstrated a TSC1 gene mutation.