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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Am J Surg Pathol. 2018 Sep;42(9):1166–1181. doi: 10.1097/PAS.0000000000001111

Figure 7.

Figure 7

Previously unclassified RCC with features of ESC now shown to harbor TSC mutation. This was a 15-year-old female who was found to have a renal tumor. The neoplasm demonstrated both solid and cystic architecture and cells with granular eosinophilic cytoplasm, typical of ESC (A, B). The cells had focally prominent nucleoli (C) and prominent plant-like cell borders (D), but lacked any evidence of granular cytoplasmic stippling that is typical of ESC. The neoplasm demonstrated patchy immunoreactivity for cathepsin K (E) and Melan A (F). This neoplasm was shown to harbor two TSC2 mutations.