Skip to main content
. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Clin Pharmacol Ther. 2017 Dec 8;104(2):364–373. doi: 10.1002/cpt.936

Figure 3. Correlation of AUC with (A) 25-gene IFN score and (B) IP-10.

Figure 3

Drug exposure (AUC24,SS) is significantly negatively correlated with 25-gene IFN score and serum IP-10 levels by F-test for AUC24,SS effect. Each individual is denoted with a different colored line and dots. The heavy red line represents the overall line for the group and the equation is listed below. (A) Correlation of AUC with 25-Gene IFN Score includes 327 observations in 18 patients (all diagnoses). The dashed line represents cutoff of normal 25-gene IFN score based on healthy controls. Equation: IFN STD 25 = 431.98 – 0.07220 (AUC24,SS), slope= −0.096 p-value for slope = 0.049. (B) Correlation of AUC with serum IP-10 levels includes189 observations in 18 patients (all diagnoses). Equation: IP-10 = 9060.45 – 2.1432 (AUC24,SS), slope= −0.197, p-value for slope = 0.0002.