Table 1.

Effect of MUC5B genotype on acute respiratory disease events: results stratified by parenchymal feature type

	Odds of reporting ARD event		Time-to-first ARD event		Number of ARD events
	OR (95% CI)	P	HR (95% CI)	P	Incident rate ratio (95% CI)	P
Entire cohort
All races (n=6663)	0.94 (0.81 to 1.10)	0.436	0.96 (0.87 to 1.06)	0.433	0.97 (0.86 to 1.09)	0.600
White (n=4999)	0.91 (0.77 to 1.07)	0.240	0.93 (0.84 to 1.04)	0.217	0.97 (0.86 to 1.10)	0.643
Black (n=1864)	1.09 (0.65 to 1.81)	0.754	1.18 (0.82 to 1.72)	0.375	0.89 (0.54 to 1.44)	0.626
Those with interstitial features
All Races (n=856)	0.54 (0.34 to 0.87)	0.010	0.67 (0.47 to 0.94)	0.020	0.65 (0.44 to 0.96)	0.030
White (n=454)	0.39 (0.22 to 0.69)	0.001	0.57 (0.38 to 0.85)	0.006	0.60 (0.40 to 0.91)	0.016
Black (n=402)	1.25 (0.48 to 3.21)	0.650	1.11 (0.55 to 2.34)	0.772	0.69 (0.28 to 1.74)	0.437
Those with emphysematous features
All races (n=1907)	1.10 (0.83 to 1.46)	0.522	1.05 (0.90 to 1.23)	0.546	1.03 (0.86 to 1.22)	0.766
White (n=1551)	1.06 (0.78 to 1.53)	0.710	1.01 (0.86 to 1.19)	0.875	1.03 (0.86 to 1.23)	0.747
Black (n=356)	0.73 (0.22 to 2.41)	0.608	0.82 (0.37 to 1.82)	0.631	0.53 (0.19 to 1.47)	0.225

All effects expressed as those with MUC5B promoter polymorphism (GT and TT) compared with those without the polymorphism (GG).

Odds of reporting an ARD event assessed using logistic regression, time-to-first ARD event assessed using Cox regression and number of ARD events assessed using negative binomial regression.

All analyses presented are adjusted for age, sex, body mass index, current smoking status, pack years of smoking, per cent predicted FEV₁, a reported history of gastro-oesophageal reflux disease, the total Saint George’s Respiratory Questionnaire Score, the clinical centre and a reported history of an ARD in the year prior to study enrolment.

ARD, acute respiratory disease.