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. Author manuscript; available in PMC: 2019 Oct 30.
Published in final edited form as: J Proteomics. 2018 Feb 13;189:75–90. doi: 10.1016/j.jprot.2018.02.008

Table 4. Selected kinomics and phosphoproteomics studies.

Topic Species (specimen) MS scan Proteins (peptides) PTMs Isotopic labeling (absolute quantification) Ref.
Breast cancer kinomics Human (MCF-7 breast cancer cell lines) SRM 150 (179) None SIL chemical tag [94]
Cancer Tyr kinomics Human (12 cancer cell lines) PRM 86 (307) None None [95]
Colorectal cancer kinomics Human (HCT116 colorectal cancer cells) PRM 173 (822) None None [96]
Drug-induced phosphorylation Human (5 cell lines) PRM 86 (96) Phosphorylation SPPS [92]
EGF-induced pTyr Human (184A1 mammary epithelial cells) SRM 144 (226) Phosphorylation iTRAQ [91]
Kinome activity during differentiation Human (HeLa, THP-1 cell lines) MS1 47 (60) Phosphorylation SPPS (pmol/(min*mg protein)) [100]
Kinome activity in cancer Human (14 cell lines, tumor) MS1 73 (90) Phosphorylation SPPS (pmol/(min*mg protein)) [99]
Kinome activity in cancer Human (9 cell lines) MS1 73 (90) Phosphorylation SPPS (pmol/(min*mg protein)) [98]
Kinomics Human (12 cell lines) SRM 83 (204) None None [44]
Kinomics Saccharomyces cerevisiae SRM 118 (214) None None [201]
Kinomics of arsenic poisoning Human (GM00637 skin fibroblast cell line) SRM 234 (245) None SILAC [202]
Kinomics of diabetes Human (HEK293T, GM00637 cell lines) SRM 328 (402) None SIL chemical tag [203]
Lung cancer kinomics Human (lung cancer tumor, cells) PRM, SRM 329 (789) None, phosphorylation None [97]
Lung, skin cancer kinomics Human (cancer cells, tumor) SRM 270 (301) None SIL chemical tag [93]
Mitochondrial phosphoproteomics Mouse (heart) SRM 7 (23) None, phosphorylation SPPS [204]