Table I.
Characteristics of Patients with Open Extremity Soft-Tissue Injuries by Post-Trauma Antibiotic Prophylaxisa .
| Characteristics, No. (%) | Total (N = 287) | Narrow (N = 212) | EGN (N = 75) | p-Value |
|---|---|---|---|---|
| Male | 283 (98.6) | 208 (98.1) | 75 (100) | 0.576 |
| Age, median years (IQR) | 24 (21, 28) | 24 (22, 28) | 23 (21, 28) | 0.764 |
| Injured in Afghanistan | 273 (95.1) | 200 (94.3) | 73 (97.3) | 0.532 |
| Injury mechanism | ||||
| Gunshot | 76 (26.5) | 62 (29.3) | 14 (18.7) | 0.074 |
| Blast | 187 (65.2) | 132 (62.3) | 55 (73.3) | 0.084 |
| Motor vehicle crash | 17 (5.9) | 13 (6.1) | 4 (5.3) | ~1.00 |
| Injury Severity Scoreb | ||||
| Median (IQR) | 11 (6, 24) | 11 (6, 24) | 12 (6, 26) | 0.206 |
| 1–9 (minor) | 126 (43.9) | 96 (45.3) | 30 (40.0) | 0.868c |
| 10–15 (moderate) | 45 (15.7) | 32 (15.1) | 13 (17.3) | |
| 16–25 (severe) | 45 (15.7) | 32 (15.1) | 13 (17.3) | |
| ≥26 (critical) | 71 (24.7) | 52 (24.5) | 19 (25.3) | |
| ICU admission | ||||
| None | 174 (60.6) | 134 (63.2) | 40 (53.3) | 0.322 |
| LRMC only | 32 (11.1) | 22 (10.4) | 10 (13.3) | |
| LRMC ± U.S. hospital | 81 (28.2) | 56 (26.4) | 25 (33.3) | |
| RBC units 24 h post-injury | ||||
| None or missing | 208 (72.5) | 155 (73.1) | 53 (70.7) | 0.341 |
| 1–9 | 64 (22.3) | 45 (21.2) | 19 (25.3) | |
| 10–20 | 9 (3.1) | 6 (2.8) | 3 (4.0) | |
| ≥21 | 6 (2.1) | 6 (2.8) | 0 | |
EGN, expanded gram-negative coverage; ICU, intensive care unit; IQR, interquartile range; LRMC, Landstuhl Regional Medical Center; RBC, red blood cell.
aExpanded gram-negative (i.e., addition of a fluoroquinolone and/or aminoglycoside to narrow coverage).
bInjury Severity Score21 is an overall measure calculated for each patient based on the top three maximum Abbreviated Injury Scale anatomical region values.
cp-Value is for the comparison of the Injury Severity Score profile between the regimen groups.