Table II.
Open Extremity Soft-Tissue Injury Outcomes by Post-Trauma Antibiotic Prophylaxis.
| Outcome, No. (%) | Total (N = 287) | Narrow (N = 212) | EGN (N = 75) | p-Value |
|---|---|---|---|---|
| Any infection at LRMC | 17 (5.9) | 10 (4.7) | 7 (9.3) | 0.145 |
| Any infection at U.S. hospital | 43 (15.0) | 32 (15.1) | 11 (14.7) | 0.929 |
| Extremity SSTI | 6 (2.1) | 6 (2.8) | 0 | 0.345 |
| Non-extremity Infections | 35 (12.2) | 24 (11.3) | 11 (14.7) | 0.447 |
| Occurrence within 2 wk of injury | ||||
| Extremity SSTI | 5 (1.7) | 5 (2.4) | 0 | 0.331 |
| MDRO isolation | 54 (18.8) | 38 (17.9) | 16 (21.3) | 0.516 |
| MRSA isolation | 3 (1.1) | 2 (0.9) | 1 (1.3) | ~1.00 |
| VRE isolation | 0 | 0 | 0 | NA |
| Occurrence within 4 wk of injury | ||||
| Extremity SSTI | 6 (2.1) | 6 (2.8) | 0 | 0.345 |
| Clostridium difficile during initial hospitalization | 2 (0.7) | 2 (0.9) | 0 | ~1.00 |
| EGN-resistant gram-negative organism isolationa | 68 (23.7) | 41 (19.3) | 27 (36.0) | 0.001 |
| Median visits to OR (IQR) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0.621 |
| Total Hospitalization, median days (IQR)b | 19 (14, 28) | 19 (14, 26) | 20 (15, 34) | 0.069 |
| Death | 2 (0.7) | 2 (0.9) | 0 | 1.000 |
EGN, expanded gram-negative coverage; IQR, interquartile range; LRMC, Landstuhl Regional Medical Center; MDRO, multidrug-resistant organism; MRSA, methicillin-resistant Staphylococcus aureus; OR, operating room; SSTI, skin and soft-tissue infection; VRE, vancomycin-resistant Enterococcus.
aRecovery of gram-negative organisms from any site that were resistant to fluoroquinolones and/or aminoglycosides.
bInjury to first discharge from U.S. participating hospital.