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. 2018 Jun 8;42(3):1695–1715. doi: 10.3892/ijmm.2018.3725

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Copyright: © Bahman et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Sequence-dependent anti-proliferative effect of combined treatment with Sora and Rsv on (A) Hep3b and (B) HepG2 hepatic cancer cell lines. The cells were treated with a combination of Sora (5 μM) and Rsv (40 or 80 μM) in (a) a sequential, (b) inverted sequential and (c) concomitant manner. Cell growth was monitored by MTT assay. Sora, sorafenib; UT, untreated; Rsv, resveratrol, ^*P<0.05 (Sora + 40 μM Rsv) vs. Sora, ^**P<0.05 (Sora + 80 μM Rsv) vs. Sora, ^***P<0.05 Sora vs. (Sora + 40 μM Rsv or 80 μM Rsv).