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. 2018 Jun 21;42(3):1353–1366. doi: 10.3892/ijmm.2018.3740

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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KEGG pathway analysis of the target genes of circRNAs. circRNAs with 2-fold change and P<0.05 were selected from the dysregulated circRNAs, and the target genes of these circRNAs were identified using bioinformatics tools. (A) The top 20 pathways of the target genes of upregulated circRNAs were identified using KEGG analysis according to the number of enriched genes. (B) The top 20 pathways of the target genes of upregulated circRNAs were identified using KEGG analysis according to the rich factor, Q value and the number of enriched genes. (C) The top 20 pathways of the target genes of downregulated circRNAs were identified using KEGG analysis according to the number of enriched genes. (D) The top 20 pathways of the target genes of downregulated circRNAs were identified using KEGG analysis according to rich factor, Q value and the number of enriched genes. KEGG, Kyoto Encyclopedia of Genes and Genomes; circRNA, circular RNA.

KEGG pathway analysis of the target genes of circRNAs. circRNAs with 2-fold change and P<0.05 were selected from the dysregulated circRNAs, and the target genes of these circRNAs were identified using bioinformatics tools. (A) The top 20 pathways of the target genes of upregulated circRNAs were identified using KEGG analysis according to the number of enriched genes. (B) The top 20 pathways of the target genes of upregulated circRNAs were identified using KEGG analysis according to the rich factor, Q value and the number of enriched genes. (C) The top 20 pathways of the target genes of downregulated circRNAs were identified using KEGG analysis according to the number of enriched genes. (D) The top 20 pathways of the target genes of downregulated circRNAs were identified using KEGG analysis according to rich factor, Q value and the number of enriched genes. KEGG, Kyoto Encyclopedia of Genes and Genomes; circRNA, circular RNA.