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. 2018 Jun 11;42(3):1327–1340. doi: 10.3892/ijmm.2018.3727

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Characterization of early EPCs derived from the STZ-induced DM mice. (A) Blood glucose and (B) body weight measurements in STZ-induced DM mice. (C) The isolated mononuclear cells became spindle-shaped following 7 days of culture. Scale bar, 500 (left) and 200 (right) μm. (D) The EPCs were identified as double positive for Dil-acLDL (red) and lectin (green) following 7 days of culture. Scale bar, 50 μm. (E) Early EPCs were further confirmed by expression of well-established cell surface markers CD34, CD133, VEGFR2 and CD45^dim. ^*P<0.05 and ^***P<0.001 compared with control (n=10). EPCs, endothelial progenitor cells; STZ, streptozotocin; DM, diabetes mellitus; Dil-acLDL, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindo-carbocyanine-labeled acetylated low density lipoprotein; VEGFR2, vascular endothelial growth factor receptor 2; FITC, fluorescein isothiocyanate.