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. 2018 May 23;42(3):1473–1483. doi: 10.3892/ijmm.2018.3704

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Copyright: © Fu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Known target genes of paeonol. The associations between the compound paeonol and genes were analyzed by the Search Tool for Interactions of Chemicals online retrieval site. Closer associations are represented by thicker lines. Protein-protein interactions are shown in grey, chemical-protein interactions shown in green, and interactions between chemicals shown in red. Associations are meant to be specific and meaningful; proteins jointly contribute to a shared function, which does not necessarily mean they are physically binding each other. VCAM1, vascular cell adhesion molecule 1; ICAM1, intercellular adhesion molecule 1; PTGS2, prostaglandin-endoperoxide synthase 2; CASP, caspase; TYR, tyrosinase.