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. 2018 Jun 28;42(3):1537–1547. doi: 10.3892/ijmm.2018.3748

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Copyright: © Yan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Lysosomal inhibitor inhibits effects of miRNA-145 upregulation on cell apoptosis in an in vitr model of AMI. Quantitative analysis of (A) P62, (B) Bax protein expression levels, and (C) representative image, detected via western blotting. (D) Cell proliferation detected via MTT assay. Quantitative analysis of (E) caspase-3 and (F) caspase -9 activities. (G) Representative image and (H) quantitative analysis of apoptosis rate detected via flow cytometry. ^##P<0.01 vs. control group; ^**P<0.01 vs. miRNA-145 overexpression group. miRNA, microRNA; control, control group; miRNA-145, miRNA-145 overexpression group; miRNA-145 + Chl, miRNA-145 overexpression and chloroquine diphosphate group; Bax, B cell lymphoma 2 associated apoptosis regulator.