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CXCR4 is expressed at a high level in first-trimester villi. (A) mRNA expression of CXCR4 in first-trimester villi and normal full-term placentas was measured by reverse transcription-quantitative polymerase chain reaction analysis. **P<0.01. (B) Immunoreactivity for CXCR4 was identified in the villous trophoblasts. The immunostaining of CXCR4 was increased in the first-trimester villi compared with that in normal full-term placentas. Scale bar=100 µm. CXCR4, CXC chemokine receptor 4.
