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. 2018 May 22;42(3):1508–1516. doi: 10.3892/ijmm.2018.3701

Figure 4.

Figure 4

Hypoxia-induced invasion and migration of JEG3 cells are decreased by CXCR4 knockdown. Specific knockdown of CXCR4 in JEG3 cells by siRNA was analyzed by (A) reverse transcription-quantitative polymerase chain reaction and (B) western blot analyses (**P<0.01). (C) Migration and invasion of JEG3 cells that were transfected with NC-siRNA or siCXCR4 and then exposed to 21 or 3% O2 were assessed by Transwell assays at a magnification of ×200. (D) Numbers of migrating or invading cells are presented as the mean ± standard deviation (*P<0.05, siCXCR4, vs. NC-siRNA; #P<0.05, vs. NC-siRNA under 21% O2). CXCR4, CXC chemokine receptor 4; siRNAS, small interfereing RNA; NC, negative control.