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. 2018 Jun 21;42(3):1411–1417. doi: 10.3892/ijmm.2018.3738

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Schematic diagram of mechanism of Kushui Rose decoction (KRD) suppressing multivulva (Muv) phenotype induced by over-activated Ras. First, over-activated Ras/MAPK pathway led to the excessive accumulation of reactive oxygen species (ROS), and then worms were treated with KRD which can scavenge ROS. Next, KRD triggered the nuclear translocation of forkhead transcription factor (DAF-16) and the expression of glutathione S-transferase-4 (GST-4), superoxide dismutase-1 (SOD-1), SOD-3, heat shock protein-16.2 (HSP-16.2) to protect the worms against oxidative stress. Finally, the level of ROS returned to normal and the Muv phenotype in let-60 (gf) mutants was reverted by KRD.