Table 1.
Adjusted geometric means, geometric mean ratios and 90% confidence intervals (CI) for primary and secondary pharmacokinetic parameters of digoxin administered alone or in the four‐component cocktail
| Endpoint | Digoxin in test cocktail (T) | Digoxin alone (R) | Ratio T/R | 90% CI | gCVa | ||
|---|---|---|---|---|---|---|---|
| N b | Adj. geom. mean | N | Adj. geom. mean | [%] | [%] | [%] | |
| AUC 0–tz [nmol·h l −1 ] | 28 | 11.55 | 28 | 11.98 | 96.39 | (88.22; 105.33) | 19.4 |
| C max [nmol l −1 ] | 28 | 1.26 | 28 | 1.36 | 93.17 | (83.49; 103.97) | 24.1 |
| AUC 0–∞ [nmol·h l −1 ] | 27 | 17.67 | 28 | 18.30 | 96.53 | (92.08; 101.20) | 10.1 |
a
Within‐subject geometric coefficient of variation.
b
N for AUC0–∞ less than N for AUC0–tz due to insufficient bioanalytically quantifiable plasma concentrations in some subjects at late sampling times to allow determination of the terminal half‐life.