Table 2.
Adjusted geometric means, geometric mean ratios and 90% confidence intervals (CI) for primary and secondary pharmacokinetic parameters of furosemide administered alone or in the four‐component cocktail
| Endpoint | Furosemide in test cocktail (T) | Furosemide alone (R) | Ratio T/R | 90% CI | gCVa | ||
|---|---|---|---|---|---|---|---|
| N b | Adj. geom. mean | N b | Adj. geom. mean | [%] | [%] | [%] | |
| AUC 0–tz [nmol·h l −1 ] | 28 | 163.61 | 30 | 159.43 | 102.62 | (93.82; 112.25) | 20.4 |
| C max [nmol l −1 ] | 28 | 86.28 | 30 | 82.99 | 103.96 | (93.60; 115.46) | 24.0 |
| AUC 0–∞ [nmol·h l −1 ] | 20 | 156.38 | 20 | 160.55 | 97.40 | (90.87; 104.41) | 9.6 |
a
Within‐subject geometric coefficient of variation.
b
N for AUC0–∞ less than N for AUC0–tz due to insufficient bioanalytically quantifiable plasma concentrations in some subjects at late sampling times to allow determination of the terminal half‐life.