Table 3.
Adjusted geometric means, geometric mean ratios and 90% confidence intervals (CI) for primary and secondary pharmacokinetic parameters of metformin administered alone or in the four‐component cocktail
| Endpoint | Metformin in test cocktail (T) | Metformin alone (R) | Ratio T/R | 90% CI | gCVa | ||
|---|---|---|---|---|---|---|---|
| N | Adj. geom. mean | N | Adj. geom. mean | [%] | [%] | [%] | |
| AUC 0–tz [nmol·h l −1 ] | 28 | 1283.80 | 29 | 1316.79 | 97.49 | (93.54; 101.61) | 9.0 |
| C max [nmol l −1 ] | 28 | 225.16 | 29 | 229.17 | 98.25 | (91.85; 105.09) | 14.7 |
| AUC 0–∞ [nmol·h l −1 ] | 28 | 1290.93 | 29 | 1324.08 | 97.50 | (93.58; 101.58) | 8.9 |
a
Within‐subject geometric coefficient of variation.