Table 4.
Adjusted geometric means, geometric mean ratios and 90% confidence intervals (CI) for primary and secondary pharmacokinetic parameters of rosuvastatin administered alone or in the four‐component cocktail
| Endpoint | Rosuvastatin in test cocktail (T) | Rosuvastatin alone (R) | Ratio T/R | 90% CI | gCVa | ||
|---|---|---|---|---|---|---|---|
| N b | Adj. geom. mean | N b | Adj. geom. mean | [%] | [%] | [%] | |
| AUC 0–tz [nmol·h l −1 ] | 28 | 81.93 | 29 | 78.02 | 105.01 | (96.39; 114.40) | 18.8 |
| C max [nmol l −1 ] | 28 | 8.14 | 29 | 7.80 | 104.28 | (94.95; 114.53) | 20.6 |
| AUC 0–∞ [nmol·h l −1 ] | 22 | 97.39 | 25 | 90.48 | 107.63 | (97.04; 119.39) | 19.4 |
a
Within‐subject geometric coefficient of variation.
b
N for AUC0–∞ less than for AUC0–tz due to insufficient bioanalytically quantifiable plasma concentrations in some subjects at late sampling times to allow determination of the terminal half‐life.