Table 3.
Fluconazole and micafungin treatment information and population pharmacokinetic results
| Fluconazole group (n = 18) | Micafungin group (n = 18) | |
|---|---|---|
| Treatment information a | ||
| Loading dose (mg kg–1 dose–1) | 25.0 (21.4–27.3) | 15.1 (12.1–18.8) |
| Maintenance dose up to day 5 (mg kg–1 day–1) | 18.6 (9.3–21.5) | 9.9 (8.1–11.4) |
| Maintenance dose from day 6 (mg kg–1 day–1) | 10.52 (4.78–20.43) | 4.76 (3.48 to 10.4) |
| Duration of treatment (days) | 6 (1–20) | 4 (1–35) |
| Pharmacokinetic parameters b | ||
| Clearance (l h–1 kg–1) | 0.015 (0.008–0.039) | 0.020 (0.010–0.023) |
| Volume of distribution (l kg–1) | 0.913 (0.913–0.913) | 0.354 (0.225–0.482) |
| t½ (h) | 40.9 (16.2–78.4) | 13.6 (9.9–21.7) |
| AUC0–24 (mg*h l–1) at day 1 | 490.9 (406.2–571.9) | 478.9 (400.6–734.4) |
| AUC0–24 (mg*h l–1) at steady state | 898.2 (503.4–1445.7) | 493.8 (437.5–1023.9) |
AUC0–24, area under the concentration–time curve from 0 to 24 h; t½, half‐life
a
Data represent median (range)
b
Data represent median (95% confidence interval)