Figure 1.

Measured and dose‐adjusted (per mg dose) steady‐state lamotrigine troughs by treatment‐by‐genotype – wild type homozygosity vs. variant allele carriage at UGT and ABC transporter loci, except for UGT1A4*2. Depicted are individual values (circles), medians (horizontal lines and numerical values), quartiles (boxes) and inner fences (bars). Values outside fences are outliers. For the lamotrigine‐treated wild type subjects at UGT1A4*2 (n = 128) measured lamotrigine troughs ranged between 0.5 and 37.6 μmol l^–1 (median 6.6) and dose‐adjusted troughs ranged between 6.5 and 318 nmol l^–1 (median 68.0). For the three variant allele carriers, the respective values were 5.2, 12.5 and 23.8 μmol l^–1 (measured) and 79.3, 104.0 and 125 nmol l^–1 (dose‐adjusted), i.e. within the wild type range. For the lamotrigine + valproate‐treated wild type subjects (n = 71), measured lamotrigine troughs ranged between 2.3 and 102 μmol l^–1 (median 25.9) and dose‐adjusted troughs ranged between 30.7 and 464 nmol l^–1 (median171.6). For the three variant allele carriers, the respective values were 6.5, 49.3 and 67.8 μmol l^–1 (measured) and 130, 247 and 339 nmol l^–1 (dose‐adjusted), i.e. within the wild type range. Data illustrate the valproate effect and do not indicate any effect of the variant allele carriage