Table 3.

Multivariate analysis (Cox regression) on the overall survival and time to leukemic change

Variables	Overall survival				Time to leukemic change
	HR	95% CI		P	HR	95% CI		P
		Lower	Upper			Lower	Upper
Agea	1.019	1.003	1.035	0.017*	0.984	0.965	1.005	0.133
IPSS-Rb	3.114	1.839	5.270	<0.001*	3.694	1.710	7.982	0.001*
SRSF2	1.092	0.501	2.379	0.825	0.913	0.294	2.837	0.875
ZRSR2	1.400	0.665	2.950	0.376	0.690	0.212	2.242	0.537
ASXL1	1.628	0.784	3.381	0.191	4.788	1.933	11.857	0.001*
EZH2	1.227	0.456	3.300	0.685	0.701	0.171	2.881	0.622
TP53	4.563	1.936	10.753	0.001*	5.009	1.250	20.079	0.023*
Aberrant AS scorec	1.801	1.019	3.181	0.043*	2.736	1.036	7.222	0.042*

HR hazard ratio, CI confidence interval

*Statistically significant (P < 0.05)

^aAge as a continuous variable

^bIPSS-R risk score > 4.5 relative to IPSS-R ≤ 4.5 (the reference)

^cHigh global aberrant AS score relative to low global aberrant AS score (the reference)