Figure 5.

The Analysis of major transition trajectories between the three cell attractors of EMT Boolean model. The major transition trajectories from (a) epithelial cells, (b) hybrid cells and (c) mesenchymal cells to other cell state attractors. The dashed bold arrows represent the escaping transition driven by noise and the solid bold arrows represent the following sequential transitions due to execution of Boolean functions. (d) This example demonstrates that inhibition of one single node µ34 (third position in the state vector) is not sufficient to block the transition from hybrid to mesenchymal attractor.