Skip to main content
. 2018 Aug 13;4:82. doi: 10.1038/s41420-018-0084-z

Fig. 6. Synergism of SC-43 and SC-78 with oxaliplatin and/or irinotecan in suppressing the sphere formation of HCT-116 and HT-29 cells.

Fig. 6

a HCT-116 and b HT-29 cells (1 × 105) were cultured in defined media containing DMSO (vehicle), 0.4 μM SC-43, 0.4 μM SC-78, oxaliplatin (2 μM in HCT-116 and 1 μM in HT-29), 2 μM irinotecan, or different combinations of the four drugs. After 7 days, spheres stained by MTT were photographed, and their numbers were quantified by MetaMorph software. Data (mean ± SD, N = 3) were analyzed by one-way ANOVA with the LSD post-hoc test; different letters represent different levels of significance (p < 0.05)