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. 2018 Aug 13;8:12003. doi: 10.1038/s41598-018-30524-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Social interaction rescued the restraint stress-induced working memory impairments. (a) Images representing restraint stress (RS) and restraint stress with the presence of conspecific mouse (RSS) conditions. (b) Scheme of Y maze test performed after an hour of RS or RSS. (c) Spontaneous alternations and (d) total arm entries were evaluated in the Y maze test (n = 10). All data are expressed as the mean ± S.E.M using bar graphs. (c) one-way ANOVA followed by Bonferroni’s multiple comparison post hoc analysis and (d) Kruskal-Wallis test followed by Dunn’s multiple comparison post hoc analysis. * is p < 0.05, *** is p < 0.001. Con: vehicle control group, RS: restraint stress group, RSS: restraint stress with social interaction group.