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. 2018 Aug 13;8:12046. doi: 10.1038/s41598-018-30509-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BET and PI3K inhibition are synergistic in BL. (A) Boxplots of CI show drug interactions of PI3K inhibitors (idelalisib), the AKT inhibitor MK-2206 and mTOR inhibitor (everolimus). CI could not be calculated for all cell lines (cell lines with values <2 are shown). (B) Relative viability (%) data in a 10 × 10 matrix experiment (mean of duplicate values) for combinations of OTX015 with idelalisib, MK-2206 and everolimus. Drugs and respective concentrations are listed on x and y axes. The effect on viability is colour coded (green viability 100%, red 1%). The diagonal box marks viability data used for constant-concentration-ratio analysis of drug interaction, which resulted in the Fa-CI plots (Fraction affected combination index³⁵). Fa-CI plot shows CI on y-axis as a function of effect level of the drug combination (Fa; fraction of dead cells compared to control) on x-axis. Data points below the horizontal line (CI = 1) indicate synergy.