Table 1.

Participant characteristics of lung cancer cases and controls in GWAS cohorts

Variants	1st Discovery cohort (n = 3900)					2nd Discovery cohort (n = 6573)					Replication Cohort (n = 32,465)
	Control (n = 1977)		Case (n = 1923)		P-value	Control (n = 3578)		Case (n = 2995)		P-value	Control (n = 14,026)		Case (n = 18,439)		P-value
	No.	%	No.	%		No.	%	No.	%		No.	%	No.	%
Age (years)
0–64	502	25.4	420	21.8	0.009	2304	64.39	1825	60.9	0.004	8449	60.2	9513	51.6	<0.0001
≥65	1475	74.6	1503	78.2		1274	35.61	1170	39.1		5577	39.8	8926	48.4
Gender
Male	1514	76.6	1520	79.0	0.06	2417	67.55	2093	69.9	0.04	8639	61.6	11,495	62.3	0.37
Female	463	23.4	403	21.0		1161	32.45	902	30.1		5384	38.4	6941	37.6
Omitted											3	0.02	3	0.02
Smoking status
Never	633	32.0	138	7.1	<0.0001	867	24.23	137	4.6	<0.0001	4415	31.5	1800	9.8	<0.0001
Ever	1339	67.7	1774	92.3		2702	75.52	2854	95.3		9930	66.5	16,341	88.6
Omitted	5	0.3	11	0.6		9	0.25	4	0.1		281	2.0	298	1.6
Histology
Squamous			488	25.4				307	10.3				4490	24.3
Adenocarcinoma			788	40.9				620	20.7				6819	37.0
Other			613	31.9				226	7.5				5487	29.8
Omitted			34	1.8				1842	61.5				1643	8.9