Table 2.
Index SNPs in the chromosome 15q25.1 locus which were associated with lung cancer with P < 5.00E-8 in the 1st discovery cohort and in meta-analysis of the discovery cohorts
| SNP | Gene | Predicted function | A1 | A2 | 1st discovery cohort | 2nd discovery cohort | Meta-analysis of discovery cohorts | replication cohort | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P-value | BONFa | P-value | BONFa | P-value | BONFa | P-value | BONFa | |||||
| rs1051730 | CHRNA3 | coding | T | C | 2.28E-14 | 7.77E-11 | 3.03E-13 | 1.04E-09 | 1.64E-25 | 5.09E-20 | 3.11E-49 | 1.06E-45 |
| rs1996371 | CHRNB4 | intronic | G | A | 9.08E-12 | 3.10E-08 | 1.15E-05 | 3.93E-02 | 2.05E-14 | 6.36E-09 | 2.83E-24 | 9.65E-21 |
| rs6495314 | CHRNB4 | intronic | C | A | 1.47E-11 | 5.01E-08 | 7.29E-06 | 2.49E-02 | 1.47E-14 | 4.56E-09 | 8.54E-24 | 2.91E-20 |
| rs8034191 | HYKK | intronic | C | T | 3.05E-11 | 1.04E-07 | 8.98E-14 | 3.07E-10 | 2.40E-23 | 7.45E-18 | 2.12E-46 | 7.23E-43 |
| rs11638372 | CHRNB4 | intronic | T | C | 3.14E-10 | 1.07E-06 | 2.95E-05 | 1.01E-01 | 8.11E-13 | 2.52E-07 | 5.28E-24 | 1.80E-20 |
| rs2036534 | HYKK | 3downstream | C | T | 3.81E-10 | 1.30E-06 | 4.29E-06 | 1.47E-02 | 7.81E-14 | 2.42E-08 | 4.85E-32 | 1.65E-28 |
| rs4887077 | CHRNB4 | intronic | T | C | 4.16E-10 | 1.42E-06 | 2.39E-05 | 8.17E-02 | 7.72E-13 | 2.40E-07 | 2.23E-23 | 7.61E-20 |
| rs6495309 | CHRNB4 | 3downstream | T | C | 3.57E-08 | 1.22E-04 | 4.29E-06 | 1.47E-02 | 2.18E-12 | 6.76E-07 | 9.34E-29 | 3.19E-25 |
aP-value was adjusted for multiple comparisons using Bonferroni correction.