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. 2018 Aug 13;8:12042. doi: 10.1038/s41598-018-30525-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The fold increase of granzymes and IL-12p70 concentrations in supernatants collected from in vitro modified DCs derived from colorectal cancer (CRC) patients blood monocytes. Autologous cancer cells lysates and tumor conditioned media (TCM) used in these analyses were collected from spherical cultures of CRC patients-derived CSCs (cancer stem cells). Bars and whiskers represent mean ± SEM (*p < 0.05 TNM I-II vs TNM III-IV, ANOVA Kruskal – Wallis test, n = 4–6).