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. 2018 Aug 13;8:12031. doi: 10.1038/s41598-018-30229-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Viral status modulates clinico-biological features of Peruvian patients with HCC. (a,b) Box-and-whiskers plots. (a) Age (years) of patients with HCC according to the HBV markers detected. (b) AFP serum levels (ng/mL) measured according to the HBV markers detected. For age and AFP comparisons, P values were provided by Kruskal-Wallis test for global comparisons of the three groups while they were obtained by Mann-Whitney U test for the comparisons of groups against each other. (c,d) Bar charts. ns, not significant. (c) Tumor nodularity according to the HBV markers detected. (d) Level of mutations affecting TERT-encoding gene according to the HBV markers detected. (c,d) Error bars represent the standard deviation. P values were provided by Chi-square test.