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. 2018 Aug 13;8:12031. doi: 10.1038/s41598-018-30229-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DNA repair gene expression correlates with HBV read-outs. (a,b) Box-and-whiskers plots. (a) Expression of four DNA repair genes stratified according to the median of HBV RNA expression in NTL (low expression group, n = 18, high expression group, n = 17). From right to left: structural maintenance of chromosome 5 (SMC5); Werner syndrome RecQ like helicase (WRN); TANK binding kinase 1 (TBK1); up regulator of cell proliferation (URGCP). (b) Expression of four DNA repair genes stratified according to the median proportion of mutated monotonous di-pyrimidines (M2Y = CpC or TpT, low mutated M2Y ratio, n = 15, high ratio, n = 17). From right to left: complex subunit, DNA damage recognition and repair factor (XPC); excision repair 4, endonuclease catalytic subunit (ERCC); N-methylpurine DNA glycosylase (MPG); DNA polymerase iota (POLI). Statistical tests for comparison were either Student t test or Mann-Whitney U test depending on the distribution of values as assessed by a F-test. (c) Graphical abstract proposal for a two-compartment model (i.e. HCC and NTL) explaining viral loads and mutations in Peruvian patients with HCC.