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. 2018 Aug 13;8:12038. doi: 10.1038/s41598-018-30369-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proteins (y-axis) with differing baseline log₂ expressions (x-axis) between the patient groups. Protein expression of several pro-inflammatory proteins is highest at baseline for patients in group 1, intermediate in group 2, and lowest in group 3 (a). Protein expression levels of various cystatins, proline-rich protein 1 (PROL1), and beta-2-microglobulin (B2M), considered to be beneficial, are lowest for group 1 patients, intermediate in group 2, and highest in group 3 (b). A collection of proteins not following the same order as in A and B (c). Measures are shown as mean ± s.e.m. and all proteins missing a specification (*, a or b) have a statistical difference between patient groups 1 and 2, and 1 and 3 (Welch’s analysis of variance). *Significant differences between all patient groups; ^aPatient group 3 differs significantly from other groups; ^bPatient groups 1 and 2 differ from each other significantly.