. 2018 Aug 13;8:12038. doi: 10.1038/s41598-018-30369-x

Table 1.

Changes in clinical signs between baseline and the visits after medication switch.

Clinical sign		Baseline values	Change from baseline
Clinical sign		Baseline values	1.5 months	3 months	6 months	12 months
Conjunctival redness	Mean	1.750	−0.286	−0.607	−0.75	−0.964
	95% CI	[1.459, 2.041]	[−0.541, −0.03]	[−0.873, −0.341]	[−1.022, −0.478]	[−1.188, −0.741]
	P^a		0.04*	<0.001***	<0.001***	<0.001***
Lid redness	Mean	0.857	−0.357	−0.214	−0.464	−0.519
	95% CI	[0.605, 1.109]	[−0.574, −0.14]	[−0.48, 0.052]	[−0.733, −0.196]	[−0.836, −0.201]
	P^a		0.004**	0.12	0.003**	0.005**
Fluorescein tear break-up time	Mean	5.393	1.786	2.179	3.214	4.444
	95% CI	[4.284, 6.501]	[0.453, 3.118]	[0.735, 3.622]	[1.531, 4.897]	[2.184, 6.705]
	P^b		0.01*	0.005**	<0.001***	<0.001***
Corneal staining	Mean	0.607	−0.429	−0.357	−0.286	−0.393
	95% CI	[0.252, 0.963]	[−0.785, −0.072]	[−0.741, 0.026]	[−0.732, 0.16]	[−0.792, 0.007]
	P^a		0.02*	0.08	0.25	0.06
Conjunctival staining (nasal)	Mean	1.393	−0.25	−0.286	−0.393	−0.179
	95% CI	[1.070, 1.715]	[−0.654, 0.154]	[−0.633, 0.062]	[−0.806, 0.02]	[−0.614, 0.257]
	P^a		0.31	0.12	0.07	0.53
Conjunctival staining (temporal)	Mean	1.571	−0.321	−0.393	−0.464	−0.357
	95% CI	[1.265, 1.878]	[−0.656, 0.013]	[−0.819, 0.034]	[−0.852, −0.077]	[−0.755, 0.041]
	P^a		0.07	0.07	0.02*	0.08
Schirmer’s test	Mean	12.000	4.214	4.964	4.786	5.429
	95% CI	[8.511, 15.489]	[1.987, 6.441]	[1.349, 8.579]	[1.288, 8.283]	[2.622, 8.236]
	P^b		<0.001***	0.009**	0.009**	<0.001***

CI, confidence interval.

*P < 0.05; **P < 0.01; ***P < 0.001; ^a2-group Wilcoxon Signed Rank Test; ^bPaired t-test.