Table 2.

Changes in clinical symptoms between baseline and the visits after medication switch.

Clinical symptom		Baseline values	Change from baseline
			1.5 months	3 months	6 months	12 months
Irritation, burning, stinging	Mean	1.143	−0.071	−0.179	−0.143	−0.143
	95% CI	[0.629, 1.657]	[−0.738, 0.595]	[−0.855, 0.498]	[−0.849, 0.563]	[−0.737, 0.451]
	Pa		0.73	0.65	0.61	0.66
Itching	Mean	1.821	−0.643	−0.821	−0.643	−0.75
	95% CI	[1.361, 2.282]	[−1.14, −0.145]	[−1.339, −0.304]	[−1.162, −0.124]	[−1.284, −0.216]
	Pa		0.02*	0.007**	0.02*	0.01*
Foreign body sensation	Mean	1.571	−0.786	−1	−0.964	−0.393
	95% CI	[1.061, 2.082]	[−1.328,−0.244]	[−1.615, −0.385]	[−1.497, −0.432]	[−1.055, 0.269]
	Pa		0.008**	0.009**	0.003**	0.30
Tearing	Mean	1.893	−0.929	−1.036	−1.393	−1
	95% CI	[1.321, 2.464]	[−1.466, −0.391]	[−1.673, −0.398]	[−1.934, −0.851]	[−1.517, −0.483]
	Pa		0.004**	0.009**	<0.001***	0.002**
Dry eye sensation	Mean	2.071	−0.357	−0.536	−0.679	−0.607
	95% CI	[1.555, 2.588]	[−0.855, 0.14]	[−0.951, −0.12]	[−1.247, −0.11]	[−1.294, 0.08]
	Pa		0.16	0.03*	0.03*	0.09

CI, confidence interval.

*P < 0.05; **P < 0.01; ***P < 0.001; ^a2-group Wilcoxon Signed Rank Test.