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The structure of TanCAR with two different scFvs “hand-in-hand”. The TanCAR is a type of bispecific T cell dealing with antigens escaping or multiple tumor antigens in relapsed B cell malignancies. The two antibodies on the CAR part are connected in tandem so that one CAR-T cell can combine two kinds of tumor antigen at the same time or binds to the tumor cell expressing either kinds of targeted antigen.
