Table 3.
1H NMR spectroscopic data (δ) for compounds 5−8a (δ in ppm, J in Hz).
| No. | 5 | 6 | 7 | 8 |
|---|---|---|---|---|
| 1 | 1.97, overlap | 1.96, overlap | 1.78, dd (12.9, 4.1) | 1.77, overlap |
| 1.41, br d (12.5) | 1.38, overlap | 1.42, overlap | 1.41, overlap | |
| 2 | 2.31, m | 2.30, m | 1.97, overlap | 1.96, overlap |
| 1.73, dd (14.4, 3.0) | 1.71, m | 1.46, overlap | 1.45, overlap | |
| 3 | 4.10, br s | 4.07, br s | 1.83, d (12.7) | 1.83, d (12.8) |
| 1.74, overlap | 1.72, overlap | |||
| 6 | 2.48, m | 2.47, m | 2.49, m | 2.50, m |
| 1.92, overlap | 1.94, overlap | 1.93, overlap | 1.94, overlap | |
| 7 | 2.55, m | 2.51, m | 2.57, m | 2.51, m |
| 1.93, overlap | 1.93, overlap | 1.95, overlap | 1.96, overlap | |
| 11 | 2.02, overlap | 1.99, overlap | 1.94, overlap | 1.92, overlap |
| 1.96, overlap | 1.94, overlap | |||
| 12 | 1.67, m | 1.59, m | 1.66, m | 1.58, m |
| 1.44, overlap | 1.47, overlap | 1.43, overlap | 1.46, overlap | |
| 14 | 3.47, br s | 3.24, br s | 3.48, br s | 3.24, br s |
| 15 | 5.76, dd (17.7, 11.0) | 5.80, dd (17.7, 11.0) | 5.77, dd (17.7, 11.0) | 5.80, dd (17.7, 11.0) |
| 16 | 4.96, br d (17.7) | 4.99, dd (17.7, 1.4) | 4.96, dd (17.7, 1.4) | 4.99, dd (17.7, 1.0) |
| 4.93, br d (11.0) | 4.95, dd (11.0, 1.4) | 4.94, dd (10.9, 1.4) | 4.95, dd (11.0, 1.0) | |
| 17 | 1.01, s | 1.05, s | 1.01, s | 1.05, s |
| 18 | 1.46, s | 1.45, s | 1.23, s | 1.24, s |
| 20 | 1.01, s | 1.01, s | 1.00, s | 1.00, s |
| OMe | 3.51, s | 3.52, s |
a
NMR data (δ) were measured at 500 MHz in CD3OD for 5, 6, and 8, and at 600 MHz in CD3OD for 7.