Figure 6.

Prevention: the effect of a single dose of CRA on steady-state TNF-α level for the case of acute inflammation in the absence (A) and presence [(B) dashed line] of a single dose of IgLC-binding peptide. (A) Simulations started at an acute inflammation steady state with 5.0 fM/min CRA influx (as in Figure 4A) and a bolus of CRA was added at this time 0. The amounts added were 0.01 fM and 10 µM for the dashed blue and full red lines respectively. (B) 10 µM of CRA was added at time 0 together with (dashed red line) or without (full red line) 1.0 nM of peptide. CRA influx was maintained at 5.0 fM/min in all cases.